肖建，男，教授，博士研究生导师。泰山学者青年专家，山东省杰出青年基金获得者, 山东省青年科技领军人才，山东省高层次人才惠才卡获得者，青岛市高层次人才绿卡获得者，山东省青年科技奖获得者。1981年6月生，山东昌乐人，中共党员。2002年本科毕业于曲阜师范大学，2005年硕士毕业于南开大学，2009年博士毕业于新加坡南洋理工大学。2009-2010年在南洋理工大学从事博士后研究。2010-2012年在中国科学院大连化学物理研究所任副研究员。2013-2014年在美国加利福尼亚州The Scripps Research Institute做博士后研究。2012年9月以高层次人才引进至bat365中文官网登录入口工作，现为青岛农业大学功能有机分子团队负责人和有机化学学科带头人, 山东省优秀硕士论文指导教师, 青岛农业大学优秀学士论文指导教师, 青岛农业大学研究生创新计划指导教师, 国家大学生创新创业训练计划指导教师。中国化学会会员，山东省青年科技创新协会会员，山东省高端化工产业委员会秘书长，山东省化学化工学会监事会监事，青岛农业大学化学工艺二级学科硕士点负责人。迄今为止，已经在Angew. Chem. Int. Ed.、Chem. Sci.等国际顶尖或权威期刊上发表SCI论文80篇，ESI高被引论文13篇，他引总次数超过2000次，最高单篇他引超过300次。主持国家自然科学基金面上项目、泰山学者青年专家项目、山东省杰出青年基金等项目12项，授权国际PCT专利2项, 授权国内发明专利24件，受邀撰写英文综述8篇，主编英文学术著作一部。首位或独立先后荣获Asian Core Program Lectureship Award、山东省自然科学二等奖，山东省青年科技奖、山东省高等学校科学技术一等奖、山东省自然科学学术创新奖、长和国际奖教学金、中国科学院大连化学与物理研究所科技创新奖等荣誉。2022年入选美国斯坦福大学发布的全球前2%顶尖科学家榜单（World's Top 2% Scientists 2022）并入围全球前2%顶尖科学家终身科学影响力排行榜。

教育背景

1998-2002 曲阜师范大学化学与化工学院 学士

2002-2005 南开大学元素有机化学研究所 硕士

2005-2009 新加坡南洋理工大学化学与生物化学系博士 (Prof Teck-Peng Loh)

工作经历

2009-2010 新加坡南洋理工大学化学与生物化学系博士后 (Prof Teck-Peng Loh)

2010-2012 中国科学院大连化学与物理研究所副研究员

2013-2014 美国The Scripps Research Institute博士后 (Carlos F. Barbas III)

科研项目

国家自然科学基金 21102142, 21702117, 21776148，21878167

国家重点研发计划 2017YFE0105200

农业部948计划 2016-X28

山东省自然科学杰出青年基金 JQ201604

山东省重点研发计划公益类专项 2017GSF218073 2018GSF118224

山东省自然科学基金面上项目 ZR2016BM07

山东省自然科学基金博士基金 ZR2017BB005

山东省自然科学基金重点基金 ZR2020KB007

山东省中青年科学家奖励基金 BS2013YY002

青岛市应用基础研究计划青年科技专项14-2-4-70-jch

青岛市应用基础研究计划科技惠民专项 16-6-2-29-nsh

药物合成与优化湖北省重点实验室开放基金 OPP2015YB01, OPP2015ZD02

青岛农业大学高层次人才启动基金 6631112323，6631115015

青岛农业大学研究生创新计划QYC201616

国家大学生创新创业训练计划201410435050

企业横向课题 6602419032

荣誉奖励

2023 《有机化学》期刊第二届青年编委会

2022入选全球前2%顶尖科学家终身成就榜

2021 山东省自然科学二等奖（首位）

2021《有机化学》第一届青年编委会

2020 山东省优秀硕士论文指导教师

2019泰山学者青年专家

2019青岛市高层次人才服务绿卡

2019 中国职工电化教育中心健康营养师培训教师

2018 The Editorial Board of Journal of Medicines Development Sciences

2018山东省高端化工产业委员会秘书长

2018山东省青年科技创新协会会员

2017 第十一届山东省青年科技奖

2017 山东省高等学校优秀科研成果奖一等奖

2017 长和国际奖教学金

2016 山东省自然科学杰出青年基金

2016 山东省自然科学学术创新奖

2016 青岛农业大学研究生创新计划

2014 青岛农业大学优秀学士论文指导教师

2015 青岛农业大学优秀学士论文指导教师

2015 The Advisory Board, Merck Index Online

2015 Asian Core Program Lectureship Award

2015 山东省高等学校优秀科研成果奖三等奖

2013 山东省高等学校优秀科研成果奖三等奖

2013青岛农业大学优秀学士论文指导教师

2012 中国科学院大连化物所科技创新奖

2010 第八届亚欧化学会议最佳墙报奖 (AES-MMEOS 2010)

2004 南开大学陈茹玉奖学金

研究兴趣与研究方向

面向国家重大战略需求和国际前沿重要科学问题，通过化学键的断裂与重组及多学科交叉与融合，解决新一代物质创造与转化过程中的重要科学问题，高效创造功能新分子，同时以合成化学为核心，面向能源、医药和材料从事相关交叉学科的研究。

Publications：

80. Pei-Zhen Dong, Bin Qiu, Xiao-De An and Xiao Jian*, Cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated ortho-quinone methides: practical access to divergent indoline-fused polycycles, Green Chem. 2022, 24, 3772. (IF = 11.034)

79. Yu Liping, Qiu Bin, Dong Peizhen, Xiao Jian * Yu Shitao*, Facile Synthesis of Spirocyclic Tetrahydroquinolines via C(sp³)–H Functionalization in a Cascade Redox Process, Synthesis 2022, 54, 1309.

78. Wang Lin-Xuan, Qiu Bin, An Xiao-De, Dong Pei-Zhen, Liu Rui-Bin and Xiao Jian*, Organocatalytic Cascade Aldimine Condensation/[1,6]-Hydride Transfer/Mannich-Type Cyclization: Sustainable Access to Indole-2,3-Fused Diazocanes, Green Chem. 2021, 23, 8181. (IF = 10.182)

77. Yang Shuo, An Xiao-De,* Qiu Bin, Liu Rui-Bin, and Xiao Jian*, Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization, Org. Lett. 2021, 23, 9100–9105. (IF = 6.555)

76. An Xiao-De,* and Xiao Jian*, Recent Advances in Hydride Transfer-Involved C(sp³)–H Activation Reactions, Org. Chem. Front. 2021, 8, 1364. (IF = 5.455)

75. Zhong-Xuan Qiu, Pei-Zhen Dong, Zhao Huai-Li, Zhao Mei-Fa, Qiu Bin,* and Xiao Jian*,

Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of N‑Heteroaromatics and Cyclic Ethers. J. Org. Chem. 2021, 86, 9299. (IF = 4.354)

74. Duan Kang, Shi Hongjin, Wang Lin-Xuan, Li Shuai-Shuai,* Xu Lubin and Xiao Jian*, Hydride Transfer Enabled Switchable Dearomatization of Indoles in the Carbocyclic Ring and the Pyrrole Ring, Org. Chem. Front. 2020, 7, 2511. (IF = 5.455)

73. Shen Yao-Bin, Wang Lin-Xuan, Sun Yun-Ming, Dong Feng-Ying, Yu Liping, Liu Qing, and Xiao Jian*, Hydride Transfer Initiated Redox-Neutral Cascade Cyclizations of Aurones: Facile Access to [6,5] Spirocycles, Org. Lett. 2020, 22, 2537. (IF = 6.555)

72. An Xiao-De, Yang Shuo, Qiu Bin, Yang Ting-Ting, Li Xian-Jiang, and Xiao Jian*, Photoredox-Enabled Synthesis of β‑Substituted Pyrroles from Pyrrolidines, J. Org. Chem. 2020, 85, 9558. (IF = 4.745)

71. Zhou Lan, An Xiao-De, Yang Shuo, Li Xian-Jiang, Shao Chang-Lun,* Liu Qing, Xiao Jian*, Organocatalytic Cascade β-C(sp³)−H Functionalization/Aromatization of Pyrrolidines via Double Hydride Transfer, Org. Lett. 2020, 22, 776. (IF = 6.555)

70. An Xiao-De and Xiao Jian*, Fluorinated Alcohols: Magic Reaction Medium and Promoters for Organic Synthesis, Chem. Rec. 2020, 20, 142. (IF = 5.387).

69. Shen Yao-Bin, Wang Lin-Xuan, Sun Yun-Ming, Dong Feng-Ying, Yu Li-Ping, Liu Qing, Xiao Jian*, J. Org. Chem. 2020, 85, 1915. (IF = 4.745)

68. Zhu Shuai, Chen Ye-Hui, Wang Yong-Bin, Yu Peiyuan, Li Shao-Yu, Xiang Shao-Hua,

Wang Jun-Qi, Xiao Jian, Bin Tan*, Organocatalytic Atroposelective Construction of Axially Chiral Arylquinones, Nat. Comm. 2019, 10, 4268. (IF = 12.353)

67. Wang Shuai, Shen Yao-Bin, Li Long-Fei, Qiu Bin, Liu Xicheng, Qing Liu, and Xiao Jian *, N-Alkylation-Initiated Redox-Neutral [5+2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines, Org. Lett. 2019, 21, 8904. (IF = 6.555)

66. Zhou Lan, Shen Yao-Bin, An Xiao-De, Li Shuai-Shuai,* Liu Qing and Xiao Jian*, Redox-Neutral β-C(sp³)−H Functionalization of Cyclic Amines via Intermolecular Hydride Transfer, Org. Lett. 2019, 21, 8543. (IF = 6.555)

65. Shen Yao-Bin, Li Long-Fei, Xiao Ming-Yan, Li Xian-Jiang, Yang Jian-Ming, Liu Qing, Xiao Jian*, Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines, J. Org. Chem. 2019, 84, 13935. (IF = 4.745)

64.  An Xiao-De, Duan Kang, Li Xian-Jiang，Yang Jian-Ming, Liu Qing, Xiao Jian*, Synthesis of Tetrahydro[1,3,4]triazepines via Redox-Neutral α‑C(sp³)−H Amination of Cyclic Amines, J. Org. Chem. 2019. 84, 11839. (IF = 4.745)

63. Sun Meng, Zhou Si-Jia, Lou Sai-Fan, Xiao Jian, Shi Feng*, Catalytic Asymmetric (4+3) Cyclizations of In Situ Generated ortho-Quinone Methides with 2-Indolylmethanols, Angew. Chem. Int. Ed. 2019, 58, 8703. (IF = 12.257)

62. Zhang Lei, Xiang Shao-Hua, Wang Jun, Xiao Jian, Wang Junqi, Tan Bin*, Phosphoric Acid Catalyzed Atroposelective Construction of Axially Chiral Arylpyrroles, Nat. Comm. 2019, 10, 566. (IF = 12.353)

61. Li Shuai-Shuai, Zhu Shuai, Chen Chunqi, Duan Kang, Liu Qing, Xiao Jian*, Hydride Transfer Involved Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety, Org. Lett. 2019, 21, 1058. (IF=6.579)

60. Zhu Shuai, Chen Chunqi, Duan Kang, Li Shuai-Shuai,* Liu Qing, Xiao Jian*, Cascade [1,5]-Hydride Transfer/Cyclization for Synthesis of [3,4]-Fused Oxindoles. Li Shuai-Shuai, J. Org. Chem. 2019, 84, 8440. (IF = 4.805)

59.  Xu Lubin, Chen Haohua, Liu Jian, Zhou Lan, Lan Yu*, Xiao Jian*, Chiral Phosphoric Acid Catalyzed Asymmetric C(sp³)–H Functionalization of Biomass-Derived 2,5-Dimethylfuran via Two Sequential Cope-Type Rearrangements, Org. Chem. Front. 2019, 6, 1162. (IF = 5.455)

58. Shen Yao-Bin, Li Shuai-Shuai, Yun-Ming Sun, Yu Liping, Zhi-Hui Hao,* Liu Qing, Xiao Jian*, Organocatalytic C(sp³)−H Functionalization of 5-Methyl-2,3-dihydrofuran Derivatives with Trifluoropyruvates via Sequential exo-Tautomerization/Carbonyl-Ene Process, J. Org. Chem. 2019, 84, 2779. (IF = 4.805)

57. Shen Yao-Bin, Li Shuai-Shuai, Yun-Ming Sun,* Liu Xicheng, Yu Liping, Liu Qing, Xiao Jian*, Formal [4 + 2] Annulation of Oxindole-Embedded ortho-Quinone Methides with 1,3-Dicarbonyls: Synthesis of Spiro[Chromen-4,3´-Oxindole] Scaffolds, J. Org. Chem. 2019, 84, 3990. (IF = 4.805)

56. Shen Yao-Bin, Li Shuai-Shuai, Liu Xicheng, Yu Liping, Liu Qing, Xiao Jian*, A New Type of Oxindole-Embedded ortho-Quinone Methide: Dearomative [4+2] Cycloaddition with 2,5-Dimethylfuran, Adv. Syn. Catal. 2019, 361, 1453 (IF = 5.123)

55. Lv Xintong, Hu Fangzhi, Duan Kang, Li Shuai-Shuai, Liu Qing, Xiao Jian*, Aromatization-Driven Cascade [1, 5]-Hydride Transfer Reaction Promoted by Fluorinated Alcohols, J. Org. Chem. 2019, 84, 1833. (IF = 4.805)

54. Wang Shuai, An Xiao-De, Li Shuai-Shuai, Liu Xicheng, Liu Qing, Hydride Transfer Initiated Ring Expansion of Pyrrolidines toward Highly Functionalized Tetrahydro-1-benzazepines,

Xiao Jian,* Chem. Comm. 2018, 54, 3833. (IF = 6.290)

53. Yu Liping, Li Shuai-Shuai, Li Weina, Yu Shitao*, Liu Qing, Xiao Jian*, Fluorinated Alcohol Promoted Reaction of Chlorohydrocarbon with Diverse Nucleophiles for Synthesis of Triarylmethanes and Tetraarylmethanes, J. Org. Chem. 2018, 83, 15277. (IF = 4.805)

52. Li, Shuai-Shuai, Lv Xintong, Ren Didi, Shao Chang-Lun, Liu Qing, Xiao Jian*, Redox-Triggered Cascade Dearomative Cyclizations Enabled by Hexafluoroisopropanol, Chem. Sci. 2018, 9, 8253. (IF = 9.556)

51. Shen Yao-Bin, Li Shuai-Shuai, An Xiao-De, Liu Qing，Liu Xicheng, Xiao Jian*, Organocatalytic Dearomative [4 + 2] Cycloadditions of Biomass-Derived 2,5-Dimethylfuran with ortho-Quinone Methides: Access to Multi-Substituted Chromanes, Org. Lett. 2018, 20, 6069. (IF = 6.579)

50. Li Shuai-Shuai, Zhou Lan, Wang Liang, Zhao Huaili, Yu Liping, Xiao Jian*, Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Facile Synthesis of dibenzo[b,e]azepines” Org. Lett. 2018, 20, 138. (IF = 6.579)

49. Zhu Shuai, Chen Chunqi, Xiao Mingyan, Yu Liping, Wang Liang*, Xiao Jian*, “Construction of the Tetrahydroquinoline Spiro Skeleton via Cascade [1,5]-Hydride transfer-involved C(sp³)-H Functionalization “on Water” Green Chem. 2017, 19, 5653. (IF = 8.586)

48. Xiao Mingyan, Ren Didi, Xu Lubin, Yu Liping and Xiao Jian*, “S_N1-type Alkylation of N-Heteroaromatics with Alcohols” Org. Lett. 2017, 19, 5724. (IF = 6.579)

47. Li Shuai-Shuai, Fu Shiheng, Wang Liang, Xu Lubin and Xiao Jian*, “t-BuOK-Mediated Oxidative C(sp³)-H Arylation of 2-Alkylazaarenes with Nitroarenes” J. Org. Chem. 2017, 82, 8703. (IF = 4.849)

46. Xiao Jian*, Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun*, Wang Chang-Yun, “Catalyst-Free Dehydrative S_N1-Type Reaction of Indolyl Alcohols with Diverse Nucleophiles on Water” Green Chem. 2016, 18, 1032. (IF = 8.586, Hot Paper, Highlighted by X-mol资讯网站，科技日报，中国网)

45. Wang Liang, Xiao Jian*, “Hydrogen-Atom Transfer Reactions”Topics in Current Chemistry, 2016, 374, 17. (IF=4.46, Invited Review)

44. Wang Liang, Xiao Jian*, “C(sp³)-H Bond Functionalization by Sequential Hydride Transfer/Cyclization: Electronic Effect and Steric Effect Controlled Regioselectivity”

Org. Chem. Front. 2016, 3, 635. (IF=4.69, Inside Front Cover, Hot Articles in March 2016)

43. Zhao Huaili, Xiao Mingyan, Wang Liang * and Xiao Jian *, “Bifunctional Thiourea Catalyzed Asymmetric Michael Addition of Anthrone to Methyleneindolinones”

RSC Adv. 2016, 6, 38588 (IF=3.108)

42. Liu Jian, Wang Xiaoxiao, Wang Liang, Xu Lubin, Hao Zhihui and Xiao Jian*, “Fluorinated Alcohol-Mediated [4+3] Cycloaddition Reaction of Indolyl Alcohols with Cyclopentadiene”Org. Biomol. Chem. 2016, 14, 11510. (IF = 3.564)

41. Dong Haoxun, Xu Lubin, Li Shuai-Shuai, Wang Liang, Shao Chang-Lun, Xiao Jian*, “Facile Synthesis of Azaarene-substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp³)-H Functionalization”

ACS Comb. Sci. 2016, 18, 604. (IF=3.168)

40. Liu Jian, Wang Xiaoxiao, Xu Lubin, Hao Zhihui, Wang Liang* and Xiao Jian *, “One Step Synthesis of 2-Alkenylchromanes via Inverse Electron-Demand Hetero-Diels-Alder Reaction of o-Quinone Methide with Unactivated Dienes” Tetrahedron 2016, 72,7642. (IF = 2.651)

39. Zhao Huaili, Wang Xiaoxiao, Wang Liang* and Xiao Jian*, “Regioselective Michael Addition of Anthrone to Methyleneindolinones”

Synthesis, 2016, 48, 2112. (IF=2.650)

38. Fu Shiheng, Wang Liang, Dong Haoxun, Yu Junqiang, Xu Lubin and Xiao Jian*, “Facile Synthesis of 2-Alkenylazaarenes via Dehydrative Coupling of 2-Methylazaarenes with Aldehydes on Water”

Tetrahedron Lett. 2016, 57, 4533. (IF = 2.193)

37. Zhang Xianhui, Li Shuai-Shuai, Wang Liang, Xu Lubin, Xiao Jian *, Zhen-Jiang Liu*, 2-Methylquinoline Promoted Oxidative Ring-Opening of N-Sulfonyl Aziridines with DMSO: Facile Synthesis of α-Amino Aryl Ketones, Tetrahedron 2016, 72, 8073. (IF = 2.651)

36. Zhu Shuai, Xu Lubin, Wang Liang*, Xiao Jian*, “Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols”

Chin. J. Org. Chem. 2016, 36, 1229. (IF=1.852)

35. Liu Qing, Dong Xu, Li Jun, Xiao Jian, Dong Yunhui,* and Liu Hui*, “Recent Advances on Palladium Radical Involved Reactions”

ACS Catal. 2015, 5, 6111 (IF=10.614)

34. Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun,* Wang Chang-Yun, Xiao Jian*, “Fluorinated Alcohol-Mediated S_N1-Type Reaction of Indolyl Alcoholswith Diverse Nucleophiles”

Adv. Syn. Catal. 2015, 357, 4023 (IF = 5.646)

(VIP and Cover Picture, Highlighted by X-mol资讯网站，科技日报，中国网) 

33. Wang Xiaoxiao, Liu Jian, Xu Lubin, Hao Zhihui, Wang Liang*, Xiao Jian*, “Friedel–CraftsAlkylation of Heteroarenes and Arenes with Indolyl Alcohols for Construction of 3,3-Disubstituted Oxindoles”

RSC Adv., 2015, 5, 101713. (IF=3.108)

32. Xu Lubin, Shao Zhuzhou, Wang Liang，Xiao Jian*, “Tandem sp³ C-H Activation/Decarboxylation of 2-Alkyl Azaarenes with Coumarin-3-Carboxylic Acid”

Org. Lett., 2014, 16, 796. (IF = 6.579)

31. Wang Liang, Xiao Jian*, “Advancement of Cascade [1,5]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)-H Bonds”

Adv. Syn. Catal., 2014, 356, 1137. (IF = 5.646)

30. Xiao Jian,*Chen Yuye, Zhu Shuai，Wang Liang, Xu Lubin, Wei Hongtao, “Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen-6-one Derivatives by Domino Reaction of 4-alkynyl-2-oxo-2H-chromene-3-carbaldehydes”

Adv. Syn. Catal., 2014, 356, 1835. (IF = 5.646)

29. Wang Liang, Xiao Jian*,LohTeck-Peng*, “Organocatalyticβ-Functionalization of Saturated Carbonyl Compounds---The State of the Art”

ChemCatChem, 2014, 6, 1183.(IF = 4.803)

28. Shao Zhuzhou, Xu Lubin, Wang Liang, Wei Hongtao, Xiao Jian,* “Catalyst-free Tandem Michael Addition/Decarboxylation of (thio)coumarin-3-carboxylic Acids with Indoles: Facile Synthesis of Indole-3-substituted 3,4-dihydro(thio)coumarins”

Org. Biomol.Chem., 2014, 12, 2185. (IF = 3.564)

27. Wang Liang,Chen Yuye, Xiao Jian*, “AlkylideneindoleniniumIons and Alkylideneindolenine: Key Intermediates for Asymmetric Synthesis of 3-Substituted Indoles”

Asian J. Org.Chem. 2014, 3, 1036. (IF = 2.788)

26. Shao Zhuzhou, Wang Liang, Xu Lubin, Zhao Huaili and Xiao Jian *,“Facile Synthesis of Azaarene-2-substituted Chromanone Derivatives via Tandem sp³ C−H Functionlization/Decarboxylation of Azaarenes with 4-oxo-4H-chromene-3-carboxylic acid”

RSC Advances, 2014, 4, 53188. (IF = 3.108)

25. Xu Lubin, Shao Zhuzhou, Wang Liang, Zhao Huaili and Xiao Jian *,” Catalyst-Free Synthesis of (Z)-2-Alkenylquinoline Derivatives via C(sp3)-H Functionalization of 2-Methylquinolines” Tetrahedron Lett. 2014, 55, 6856. (IF = 2.35)

24. Yu Xinzhang, Yu Songjie, Xiao Jian, Wan Boshun, Li Xingwei*, “Rhodium(III)-Catalyzed Azacycle-Directed Intermolecular Insertion of Arene C−H Bonds into α-Diazocarbonyl Compounds”

J. Org. Chem. 2013, 78, 5444. (IF = 4.849)

23. Xiao Jian*, “Merging Organocatalysis with Transition Metal Catalysis: HighlyStereoselective Alkylation of Aldehydes”

Org. Lett. 2012, 14, 1716. (IF = 6.579) (Highlighted by Synfacts 2012, 8, 0749)

22. Xiao Jian*,“Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes”

ChemCatChem 2012, 4, 612. (IF = 4.803)

21. Liang Tao, Xiao Jian*, Xiong Zhiyi，Li Xingwei*, “Organocatalytic Asymmetric 1,4 Addition of Aldehydes to Acridiniums Catalyzed by a DiarylprolinolSilyl Ether”

J. Org. Chem. 2012, 77, 3583. (IF =4.849)

20. NiuRui, Xiao Jian*, Liang Tao, Li Xingwei*, “Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-Oxindoles via Bronsted Acid-Catalyzed sp³C-H Functionalization”

Org. Lett., 2012, 14, 676. (IF = 6.579)

19. Xiao Jian, Zhao Kai, LohTeck-Peng*,“The OrganocatalyticEnantioselective Acid Free Alkylation of Aldehydes in Fluorinated Alcohols”

Chem. Comm. 2012, 48, 3548. (IF = 6.57)

18. Huang Fen, Xu Lubin, Xiao Jian*, “OrganocatalyticEnantioselectiveDehydrogenative α-Alkylation of Aldehydes with Benzylic Compounds”

Chin. J. Chem. 2012, 30, 2721. (IF = 1.010)

(Invited Special Issue of "Asymmetric Synthesis", one of the most accessed papers from 11/2012 to 10/2013).

17. NiuRui, Yang Shiying, Xiao Jian*, Liang Tao, Li Xingwei*, “Yb(OTf)₃-Catalyzed Addition of 2-methylAzaarenesto Isatins via C-H Functionalization”

Chin. J. Catal. 2012, 33, 1636. (IF = 2.813)

16. Wang Xiaowei, Li Xuting, Xiao Jian, Jiang Yi, Li Xingwei*, “Rh(III)-Catalyzed Oxidative Olefination of N-(Naphthalen-1-yl)amides”

Synlett, 2012, 1649. (IF = 2.151)

15. Xiao Jian, Zhao Kai, LohTeck-Peng*,“Highly Enantioselective Intermolecular Alkylation of Aldehydes with Alcohols by Cooperative Catalysis of DiarylprolinolSilyl Ether with Brønsted Acid” Chem. Asian J. 2011, 6, 2890. (IF = 4.083)

14. Xiao Jian and Li Xingwei*, “Gold a-Oxo Carbenoids in Catalysis: Catalytic O-Atom Transfer to Alkynes”

Angew. Chem. Int. Ed. 2011, 50, 7226. (IF = 12.1)

13. Xiao Jian, Lu Yun-Peng, Liu Yan-Ling, Wong Poh-Shen, LohTeck-Peng*, “A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly EnantioselectiveOrganocatalytic Michael Addition of Aldehydes to Vinyl Sulfones”

Org. Lett. 2011, 13, 876.(IF = 6.579)

12. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, Liu Yan-Ling, LohTeck-Peng*, “Highly Efficient and Modularly Tuned Bicyclic Organocatalyst for the Enantioselective Michael Addition of Aldehydes to Nitroalkenes”

Synthesis-Stuttgart, 2011, 1292. (IF = 2.650)

11. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, LohTeck-Peng*, “Chemzymes: A New Class of Structurally Rigid Tricyclic Amphibian Organocatalyst Inspired by Natural Product”

Org. Lett. 2010,12, 1220. (IF = 6.579) (Highlighted by Synfacts 2011, 5, 0561)

10. Xiao Jian, Wong Zhen-Zhou, Lu Yun-Peng, LohTeck-Peng*, “Hexahydropyrrolo[2,3-b]indoles: A New Class of Structurally Rigid Tricyclic Skeleton for Oxazaborolidine-Catalyzed Asymmetric Borane Reduction”

Adv. Synth. Catal. 2010, 352, 1107. (IF = 5.646)

9. Xiao Jian and Loh Teck-Peng*,“The OrganocatalyticEnantioselective Michael Addition of Aldehydes to Vinyl Sulfones in Water”

Synlett, 2010, 2029. (IF = 2.151)

8. Xiao Jian and Loh Teck-Peng*, “Design, Synthesis and Optical Resolution of New Bifunctional Ligand: 1,1′-Dimethyl-octahydro-8,8′-Biquinoline-7,7′-diol”

Org. Lett. 2009, 11, 2876. (IF = 6.579)

7. Xiao Jian and Loh Teck-Peng*, “Unexpected Domino Ring Closure: Highly Stereoselective Construction of a Tetracyclic Indole Alkaloid Ring System”

Tetrahedron Lett. 2008, 49, 7184. (IF = 2.193)

6. Xiao Jian and Loh Teck-Peng*, “Design and Synthesis of a Water-Tolerant Chiral Indium Complex: Application to One-Pot Three-Component Mannich-Type Reactions in Water”

Synlett, 2007, 815. (IF = 2.151)

5. Xiao Jian, Lu Yong-Na, Wang Guo-Cang, Li Jin-Shan et al., “3-(3H-Inden-1-ylmethyl)-2,2'-bis(methoxymethoxy)1,1'-binaphthalenyl”

Acta Crystallographica Section E, 2005, 61, O1501.

4. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, et al., “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Arylantimony Derivatives of Analogues of Demethylcantharimide”, J. Organomet. Chem., 2004, 689, 1631. (IF = 2.4)

3. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, Li Jin-Shan, “Synthesis, Characterization and in Vitro Cytotoxicity Screening of Some Triarylbismuth(V) di(N-salicylidene) Amino Carboxylates and the Crystal Structure of (2-HOC₆H₄CH=NCH₂CO₂)₂Bi(C₆H₅)₃”

Appl. Organomet. Chem., 2005, 19, 113. (IF = 2.4)

2. Wang Guo-Cang, Lu Yong-Na, Xiao Jian, Li Jin-Shan, “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Organoantimony Arylhydroxamates”

J. Organomet. Chem. 2005, 690, 151. (IF = 2.4)

1. Guo Qun-Sheng, Lu Yong-Na, Liu Bing, Xiao Jian, Li Jin-Shan, “A Facile Synthesis of 3 or 3,3′-Substituted Binaphthols and Their Applications in the Asymmetric Addition of Diethylzinc to Aldehydes”

J. Organomet. Chem. 2006, 691, 1282. (IF = 2.4)

授权专利：

24 肖建；安孝德；杨烁；刘瑞宾 吲哚3,4位并九元中环化合物及其制备方法 专利号  ZL202110648541.5

23 董凤英，肖建，段康 含吲哚骨架化合物区域选择性去芳构化的方法 专利号  ZL202010068700.X

22 董凤英，肖建，段康 具橙酮骨架类化合物作为受体进行反-Micheal加成反应的方法 专利号  ZL202010068699.0

21. 肖建， 周兰 分子间氢迁移引发环胺β-C(sp3)–H官能化合成β-取代的吡咯烷类化合物的方法 专利号  ZL201910832845.X

20. 肖建， 周兰 一种通过分子间氢迁移合成β-取代的烯胺类哌啶化合物的方法专利号  ZL201910832866.1

19. 肖建， 周兰 一种β-C(sp3)–H官能化和芳构化的吡咯类化合物的合成方法专利号  ZL201910832853.4

18 肖建， 王帅 一种吲哚-1,2-并1,4-苯并二氮杂卓类化合物及其合成方法 专利号  ZL201910801207.1

17 于丽萍， 于世涛， 肖建 一种三氟甲基取代的2-甲基二氢呋喃并色满骨架化合物的合成方法 专利号 ZL201810928343.3

16. 于丽萍， 于世涛， 肖建 一种通过异硫氰酸酯与2-磺酰烷基苯酚合成苯并[1,3]噁嗪-2-硫酮的合成方法 专利号 ZL201810980752.7

15. 肖建， 沈耀斌 通过二甲基呋喃与含氧化吲哚邻羟基苄醇合成螺-色满-4,3′-氧化吲哚的合成方法 专利号  ZL201810967990.4

14. 肖建， 沈耀斌， 段康 基于生物质源2,5-二甲基呋喃去芳香化环加成策略构建多取代色满化合物的合成方法 专利号  ZL201810927561.4

13. 肖建，朱帅,李帅帅“一种基于氮原子α位氢迁移策略的吲哚碳环去芳香化合成方法”

专利号：ZL201810733984.2

12. 肖建，朱帅,李帅帅“一种氮杂环取代对醌骨架螺环化合物的合成方法”

专利号：ZL201810733970.0

11. 肖建，李帅帅，朱帅,“一种苯酚类化合物的苄基化合成方法”

专利号：ZL201810725188.4

10. 肖建，沈耀斌,“通过二甲基呋喃与含氧化吲哚邻羟基苄醇合成螺-色满-4,3′-氧化吲哚的合成方法” 专利号：ZL201810967990.4

9. 肖建，沈耀斌, 段康,“基于生物质源2, 5-二甲基呋喃去芳香化环加成策略构建多取代色满化合物的合成方法” 专利号：ZL201810927561.4

8. 肖建，朱帅,“一种合成吲哚取代或二茂铁取代氮杂芳烃的方法”

专利号：ZL 201710442072.5

7. 肖建，朱帅，“一种克霉唑的合成方法”

  专利号：ZL201711098933.9

6. 肖建，朱帅，“一种八氢二吡咯并喹啉类化合物的制备方法”

专利号：ZL201711254567.1

5. 肖建，王帅，“一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法”

专利号：ZL201810979889.0

4. 肖建，朱帅，“一种二苯并[b,e]吖庚因类化合物的制备方法”

专利号：ZL201711248907.X

3. 肖建，徐鲁斌，邵朱宙，“3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法”专利号：ZL201510679157.6

2. Loh Teck-Peng* and Xiao Jian “Process for Preparation of Octahydrobiquinoline Compounds”, PCT International Patent Application, 2010, 59pp. Patent Number: WO 2010132029

1. Loh Teck-Peng* and Xiao Jian “Preparation of Tricyclic Chiral Compounds and Their Use in Asymmetric Catalysis”, PCT International Patent Application, 2010, 141pp. Patent number: WO2010027334

 

祝贺课题组长肖建教授2022年入选全球前2%顶尖科学家“终身榜”！

祝贺课题组长肖建教授2021年荣获山东省自然科学二等奖！

祝贺课题组长肖建教授2019年获评泰山学者青年专家！

 

课题组简介

功能有机分子实验室成立于2013年3月，致力于发展绿色高效的物质转化合成方法学及功能有机分子的设计合成及应用。以绿色化学为核心，发展原子经济性的绿色有机合成化学。具体包括：（1）发展氢迁移策略的碳氢键活化及官能化反应；（2）新试剂制备及新反应发现；3. 新催化剂设计及新催化体系建立；4. 药物合成新工艺新路线开发；5. 活性分子活性评价，发现先导化合物。实验室面积400 m²，课题组成员教授1名，副教授2名，讲师1名，研究生14人，本科生10人。实验室拥有500M核磁共振仪、高效液相色谱仪、高效气相色谱仪、气相-质谱联用仪、旋光仪、低温反应仪以及常规有机合成设备，具备承担各项基础研究与应用研究的条件。本课题组热烈欢迎各高校、科研院所及企业与我们在功能分子的合成及应用等方面进行广泛的交流与合作。热烈欢迎优秀的本科生报考本课题组的研究生！热烈欢迎有志于投身科研事业的优秀博士加入我们的团队！

 

2015年

 

2014年

2013年

 

 

 

课题组老师

安孝德，邱斌，孙云明，董风英

在读研究生：

研究生三年级：邵大营、时亚飞、王忠霖

研究生二年级：汪燕平、范小梦、杨帆、王惠芸

研究生一年级：庄乾浩、王晓琳、张雨涵、王子康、郭书魁

 

 

已毕业研究生：

2014 陈雨叶 去向：免试攻读澳门大学博士研究生

2015 邵朱宙 去向：免试攻读南京大学博士研究生

2016 赵怀丽 去向：齐鲁理工学院

2016 王潇潇 去向：青岛陆橘科技有限公司

2017 董浩训 去向：潍坊市康华生物技术有限公司

2017 付士恒 去向：鲁西集团股份有限公司

2017 任文录 去向：北京药素科技有限公司

2018 朱  帅 去向：复旦大学博士研究生

2018 刘  健 去向：青岛海利尔药业有限公司

2019 沈耀滨 去向：中科院成都有机博士毕业，任职枣庄学院讲师

2019 周  兰 去向：免试攻读武汉大学博士研究生

2019 肖明艳 去向：中国海洋大学博士研究生

2020 段  康 去向：免试攻读暨南大学博士研究生

2020 吕心童  去向：攻读中科院海洋研究所博士研究生

2021 王琳璇 去向：免试攻读山东大学博士研究生

2021 李龙飞 去向：康龙化成新药技术有限公司

2022 董培桢 去向：免试攻读山东大学博士研究生

2022 杨  烁 去向：免试攻读山东大学博士研究生